The partnership will see the development of young Wolves players enhanced by sending them on loan to play senior football in a alternative environment and competitive league.
In return, FC Jumilla will benefit from sending their coaches and staff on scheduled trips to Wolverhampton, where they will learn from expert Wolves coaches and backroom staff.
Based in the south-east region of Murcia, FC Jumilla were founded in 2011 and currently play in the third tier of Spanish professional football.
A number of young Wolves players are expected to link up with the Spanish side in the coming months, to get a taste of football on the continent and learn and train in a different climate and environment.
Wolves sporting director Kevin Thelwell said: “We are always looking at ways in which we can improve and develop our young players and we believe this partnership is a natural next step for Wolves.
“Many Premier League clubs have similar relationships with overseas sides, and it will provide our young players with an opportunity to play mens football in a more challenging and stimulating environment than we can sometimes find for them in the UK.
“An extended period of time playing abroad will not only develop our players as footballers, but also as individuals, and this is also a very important factor for us.
“FC Jumilla are a young and ambitious club and we are looking forward to working with them over this season and beyond.”