In four seasons at Molineux, Nuno has led Wolves to the Premier League as EFL Championship champions and recorded back-to-back seventh placed finishes in the top-flight.
His side became the first Wolves team to reach the quarter-finals of European competition for nearly 50 years, and he will exit the club as its fifth longest serving manager of the post-war era.
Nuno said: “Since the first day we arrived at Compton, our ambition was to make a positive change and push this football club forward, and I am proud to say that we did that every single day. We achieved our goals, we did it with passion and we did it together.
“Firstly, I want to thank the supporters, who have all played such an important part in helping us reach new heights for Wolves, and the people of the city, who embraced us and made us feel at home.
“I, of course, want to thank all of the staff at Wolves, for their support and total commitment, every single day.
“Most importantly, I want to thank each-and-every player that we’ve worked with since the day we started, for their loyalty, their dedication, hard work and talent. They are the ones who have made this amazing journey possible for us.
“Sunday will be a very emotional day, but I am so happy that the fans will be back in Molineux and we can share one last special moment together, as one pack.”
Executive chairman Jeff Shi said: “Nuno has brought us some incredibly special moments at Wolves that will never be forgotten, but every chapter comes to an end.
“His loyalty and dedication over the last four years has been immeasurable, and we cannot thank him enough for the progress he has made for Wolves.
“Sunday was already going to be a very special day, welcoming our supporters back for the first time in more than a year; but it will also now be a fitting goodbye for someone who will forever remain an important part of Wolves history.”