In his first 166 matches in charge of the club, the Portuguese head coach has stuck with a back five, with three in the middle and two wing-backs.
However, for game 167, he switched to a back four, something that Wolves haven't played since their final match before Nuno's tenure, a 1-0 home win over Preston North End in May 2017.
Not a single member of the team that day was present in Monday night's line-up, but can you name the 18-man squad from that Preston win which brought an end to the 2016/17 Championship season? Take the latest Wolves Trivia quiz and let us know how you got on #WolvesTrivia.