The Wolves boss named an unchanged team after last weekend's 1-0 win away at Ipswich, and his side made the perfect start as Ruben Neves' sublime goal put them in front inside seven minutes, and Diogo Jota rounded off a stunning team move to double the lead on the half hour.
Ivan Cavaleiro's deflected free-kick put the icing on the cake 15 minutes from time, ensuring that Wolves maintained their 11-point lead over the chasing pack.
After the game, Nuno said: "It was a very good performance from the boys, in all aspects of the game - defensively, offensively, with and without the ball. We knew it would be a tough challenge against a team that beat us in the reverse fixture, but we prepared well and were well organised and played some good football. This showed the character of the team.
"The early goal changes everything. It was a fantastic goal, and the second one was really good as well. Our fans are happy today because they've seen really good football and really good goals from a team that fights and works hard.
"We always try to improve, and I'm really happy with that."
Nuno emphasised the importance of the work ethic of his team, which was once again hugely appreciated by another near-full house at Molineux.
"The fans want to see good things, and it's our job to reward the support of our fans," he continued.
"The boys in the team, the boys outside the team - they all work hard together and enjoy their football together. They make each other better because of how hard they all work - this is the spirit of the team.
"The day of the game is when we get to analyse what we've done, and we've done things right. We've been working hard, and the spirit of the team is stronger. We are focused and working hard, and playing well.
"The focus always remains on our game. It's a sign of a good team - we want to play over and over again, to improve. It's a question of how we play. We still have a long way to go - all our focus now is on QPR next week."
Nuno also confirmed that Jota was "a little bit dizzy but ok" after the high challenge from Blades goalkeeper Simon Moore, which earned him a red card and led to the free-kick from which Cavaleiro scored, but was keen to absolve the visiting goalkeeper of any blame.
"The goalkeeper goes out - and remember, I was a goalkeeper - and sometimes you run out of time and you can't stop. He's a big guy and he's jumping in the air and he can't stop. There's no intention to harm Diogo at all."
